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Updated: May 3, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Cognitive function in multiple sclerosis: a subcortical pattern of neuropsychological impairment?
C Caltagirone1, G A Carlesimo1, L Fadda1
1Neurologic Clinic, 2nd University of Rome, Ospedale S. Eugenio, P. le dell'Umanesimo, 10, 00144 Roma, Italy.
Abstract:
In order to evaluate cognitive impairment in multiple sclerosis (MS) neuropsychological tests were administered to 25 patients with clinically definite disease. Four (16%) showed diffuse cognitive impairment, whereas the others, compared with controls showed a specific deficit on tests known to be sensitive to frontal lobe damage. These results are interpreted in the light of current hypotheses relating to subcortical contributions in cognition.
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