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Hallucinations and parkinsonian motor fluctuations
W Fernandez1, G Stern1, A J Lees1
1University College and Middlesex Hospital School of Medicine, Department of Neurology, Mortimer Street, London W1N 8AA, UK.
Behavioural Neurology
|February 4, 2014
Summary
Older age and cognitive impairment are linked to hallucinations in Parkinson's disease patients. Visual hallucinations, often occurring during "off periods," improved with L-dopa treatment, suggesting a connection to motor fluctuations.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Parkinson's disease is a progressive neurodegenerative disorder.
- Hallucinations are a common non-motor symptom in Parkinson's disease, particularly with long-term treatment.
- The relationship between disease characteristics and hallucination occurrence requires further investigation.
Purpose of the Study:
- To compare patients with Parkinson's disease who experience hallucinations with those who do not.
- To identify clinical factors associated with hallucinations in Parkinson's disease.
Main Methods:
- Retrospective case-control study.
- Comparison of 30 Parkinson's disease patients with hallucinations to 20 without.
- Analysis of disease duration, L-dopa treatment, disease severity, age, and cognitive function.
Main Results:
- No significant differences in disease duration, L-dopa treatment, or severity were found between groups.
- Patients experiencing hallucinations were significantly older and exhibited greater cognitive impairment.
- Visual hallucinations, often linked to "off periods," improved with L-dopa.
- Auditory hallucinations were present in one-third of hallucinating patients.
Conclusions:
- Age and cognitive impairment are key factors associated with hallucinations in Parkinson's disease.
- Hallucinations, particularly visual ones, may be linked to motor fluctuations and L-dopa response.
- Further research into the mechanisms and management of hallucinations in Parkinson's disease is warranted.
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