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Future prospects for tissue engineered lung transplantation: decellularization and recellularization-based whole lung
Tomoshi Tsuchiya1, Amogh Sivarapatna2, Kevin Rocco2
1Division of Surgical Oncology; Department of Surgery; Nagasaki University Graduate School of Biomedical Sciences; Nagasaki, Japan.
Organogenesis
|February 4, 2014
Summary
Laboratory-engineered lungs offer hope for transplant patients facing donor shortages. Decellularization and recellularization techniques show promise for creating functional, bioengineered lungs for future clinical use.
Area of Science:
- Regenerative Medicine
- Biomedical Engineering
- Thoracic Surgery
Background:
- Donor lung shortages lead to significant patient mortality.
- Tissue engineering aims to create functional organs for transplantation.
- Advances in stem cell biology and scaffold development enable organ bioengineering.
Purpose of the Study:
- To review decellularization and recellularization strategies for bioengineering lungs.
- To discuss methods for improving lung bioengineering processes.
- To explore future prospects in lung bioengineering.
Main Methods:
- Organ decellularization to create biological scaffolds.
- Recellularization of scaffolds with appropriate stem/progenitor cells.
- Assessment of recellularized organ function and maturation.
Main Results:
- Recellularized organs demonstrate short-term, organ-specific functions.
- Decellularization and recellularization show potential for generating transplantable lungs.
- Ongoing research focuses on improving cell integration and organ maturation.
Conclusions:
- Bioengineered lungs hold significant potential to address the organ donor deficit.
- Further research is needed to optimize decellularization, recellularization, and maturation processes.
- Lung bioengineering represents a promising future direction for treating end-stage lung disease.
