Association between serum uric acid level and diabetic peripheral neuropathy (A case control study)
Javad Kiani1, Zahra Habibi2, Ali Tajziehchi3
1Department of Endocrinology, Department of Internal Medicine, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
Caspian Journal of Internal Medicine
|February 4, 2014
Summary
Diabetic patients with diabetic neuropathy (DPN) have higher serum uric acid levels compared to those without DPN. This finding suggests a potential link between uric acid and the development of DPN.
Area of Science:
- Endocrinology
- Neurology
- Nephrology
Background:
- Uric acid is implicated in diabetic complications like nephropathy and retinopathy.
- Diabetic neuropathy (DPN) is a common complication in diabetes mellitus.
Purpose of the Study:
- To investigate serum uric acid levels in diabetic patients with and without DPN.
- To explore the association between serum uric acid and the presence of DPN.
Main Methods:
- A case-control study involving 42 patients with DPN and 42 controls without DPN.
- Patients were matched for age, gender, BMI, and diabetes duration.
- Diabetic neuropathy diagnosis was confirmed via nerve conduction studies.
Main Results:
- Demographic characteristics were similar between groups, except for a higher incidence of diabetic foot ulcers in the DPN group.
- Mean serum uric acid was significantly higher in patients with DPN (4.70±0.96 mg/dl) compared to those without DPN (4.36±0.89 mg/dl).
- The difference in serum uric acid levels between groups was statistically significant (p=0.019).
Conclusions:
- Elevated serum uric acid levels are associated with diabetic neuropathy in diabetic patients.
- Further research is needed to elucidate the role of uric acid in DPN development and progression.
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