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Updated: May 3, 2026

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
Published on: July 6, 2022
[Clinical natural development in human meniscus injury]
X u Hong-hai1, Feng Zhang2, Ning Liu2
1Third Affiliated Hospital, Medical College of Xi'an Jiaotong University,Xi'an 710068, Shaanxi,China. xuhonghai1963@126.com
Untreated meniscus injuries worsen with activity, increasing pain and damage. Early diagnosis, treatment, and immobilization are crucial for healing and preventing further surgery.
Area of Science:
- Orthopedic Surgery
- Sports Medicine
- Histology
Background:
- Meniscus injuries are common in knee trauma.
- The natural healing process and histological changes of untreated meniscus injuries are not fully understood.
Purpose of the Study:
- To investigate the clinicopathological changes of untreated meniscus injuries.
- To provide a theoretical basis for clinical treatment strategies.
Main Methods:
- 32 patients with meniscus injuries underwent arthroscopy and total meniscectomy.
- Histological analysis of meniscus wound edges using light and electron microscopy.
- Preoperative and postoperative Lysholm scores were used for clinical evaluation.
Main Results:
- Significant improvement in Lysholm scores post-treatment.
- Arthroscopy revealed typical differences in wound edges in 28 cases.
- Microscopic analysis showed cellular changes indicative of attempted healing and atrophy at the wound edges.
Conclusions:
- Untreated meniscus injuries can worsen with activity, leading to increased symptoms.
- Early diagnosis, treatment, and immobilization are vital for meniscus injury healing.
- Total meniscectomy is a satisfactory treatment for irreparable meniscus injuries.
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