Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

398
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
398
Allergic Reactions02:06

Allergic Reactions

26.4K
Overview
26.4K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

280
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
280
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

627
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
627
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.4K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.4K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seasonal trade-offs shape metabolomic and proteomic responses to Varroa destructor parasitisation in honey bees (Apis mellifera).

Insect biochemistry and molecular biology·2026
Same author

Designing an effective fall preparedness and recovery program for older adults: an e-Delphi study.

BMC geriatrics·2026
Same author

Seafood Allergen Transfer in a Shared Breading System.

Journal of food protection·2026
Same author

Prenatal Cannabis Use and Neonatal Outcomes: A Systematic Review and Meta-Analysis.

Obstetrical & gynecological survey·2026
Same author

In Their Own Words: A Qualitative Exploration of Veterans' Perspectives and Experiences of Medical Cannabis Use.

Journal of general internal medicine·2026
Same author

Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel.

Nature communications·2025
Same journal

Safety and digestibility evaluation of L-β-galactoglucan: Implication for its use as a novel food ingredient.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same journal

Preclinical Toxicological Evaluation of 7-Methoxy-3-Phenyl-4H-Chromen-4-one: Acute and Sub-acute Oral Toxicity with Histopathological Correlation.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same journal

Redox-dependent cytoprotection by zerumbone via Nrf2-Keap1 mediated restoration of antioxidant and apoptotic balance in Mancozeb-exposed cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same journal

Dihydroberberine in Metabolic Disorders: Bioavailability, Molecular Mechanisms, Toxicology, and Future Perspectives.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same journal

RIFM fragrance ingredient safety assessment, linoleic acid, CAS Registry Number 60-33-3.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same journal

ORGAN-SPECIFIC RESPONSES OF AGE-DEPENDENT VULNERABILITY TO DEOXYNIVALENOL IN FEMALE MICE.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.9K

Translating reference doses into allergen management practice: challenges for stakeholders.

René W R Crevel1, Joseph L Baumert2, Stefano Luccioli3

  • 1Safety and Environmental Assurance Centre, Unilever, Colworth House, Sharnbrook, Bedford, UK.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|February 5, 2014
PubMed
Summary
This summary is machine-generated.

This study proposes a risk analysis framework to manage allergen cross-contact, improving decision-making by linking risk assessment to clear management goals and communication for stakeholders.

Keywords:
Eliciting doseFood allergyProbabilistic modellingPublic healthReference doseRisk assessment

More Related Videos

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.9K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K

Related Experiment Videos

Last Updated: May 3, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

4.9K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.9K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.9K

Area of Science:

  • Food safety science
  • Allergen management
  • Risk analysis

Background:

  • Risk assessment is foundational for risk management but not its conclusion.
  • Allergen cross-contact presents significant challenges in food safety decision-making.
  • Current approaches often lack clear, science-based benchmarks, leading to confusion.

Purpose of the Study:

  • To outline a comprehensive risk analysis framework for allergen cross-contact.
  • To identify and address challenges in risk assessment, management, and communication.
  • To facilitate science-based decision-making and clear allergen labeling.

Main Methods:

  • Development of a risk analysis framework integrating risk assessment, management, and communication.
  • Identification of data gaps and interpretation challenges in risk assessment.
  • Emphasis on clear objectives for risk management and stakeholder engagement.

Main Results:

  • The framework translates risk assessment outputs into feasible risk management objectives.
  • It promotes understanding of model limitations and stakeholder-accepted risk levels.
  • Clear, consistent, and trustworthy communication is highlighted as crucial.

Conclusions:

  • A science-based framework can improve allergen management and labeling clarity.
  • Adaptability to new evidence is essential for the proposed framework.
  • Integrating stakeholder perspectives leads to achievable and accepted risk management strategies.