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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
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Elevated fasting serum insulin level predicts future development of hypertension
Sung Keun Park1, Ju Young Jung2, Won Joon Choi3
1Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
International Journal of Cardiology
|February 5, 2014
Summary
Elevated fasting insulin levels significantly increase hypertension risk over time. This study found hyperinsulinemia to be an independent risk factor, suggesting fasting insulin as an early hypertension predictor.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Preventive Medicine
Background:
- The clinical association between fasting insulin and hypertension is debated.
- The long-term risk of hypertension due to elevated fasting insulin remains unclear.
Purpose of the Study:
- To investigate the association between baseline fasting insulin levels and the future development of hypertension.
- To determine if hyperinsulinemia is an independent risk factor for hypertension.
Main Methods:
- A cohort of 25,062 non-diabetic Korean men was followed from 2005 to 2010.
- Participants were stratified into four groups based on baseline fasting insulin levels.
- Cox proportional hazards models were used to assess hypertension incidence and risk.
Main Results:
- Hypertension incidence increased progressively with higher baseline fasting insulin quartiles (13.3% to 23.2%, P<0.001).
- Adjusted hazard ratios for hypertension were significantly elevated in the second, third, and fourth insulin quartiles compared to the first (P for trend<0.001).
Conclusions:
- Hypertension risk is directly proportional to baseline fasting insulin levels.
- Hyperinsulinemia is an independent risk factor for developing hypertension.
- Fasting insulin level shows potential as an early predictor for hypertension.
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