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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Drugs that Stabilize Microtubules01:15

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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: May 3, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

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MicroRNAs and anticancer drugs.

Zhiwei Xing1, Dongsheng Li, Ling Yang

  • 1Clinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China.

Acta Biochimica Et Biophysica Sinica
|February 5, 2014
PubMed
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MicroRNAs (miRNAs) regulate gene expression and are involved in cancer. This review explores their role in chemoresistance and potential as targets for novel anticancer drugs.

Keywords:
cancerchemoresistancechemotherapymicroRNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNA molecules regulating gene expression post-transcriptionally.
  • miRNAs are implicated in various cellular processes, including tumorigenesis and cancer progression.
  • They show potential as biomarkers and therapeutic targets in oncology.

Purpose of the Study:

  • To review recent literature on miRNA and anticancer drugs.
  • To elucidate molecular mechanisms of chemoresistance involving miRNA regulation.
  • To provide insights for developing novel anticancer therapeutics.

Main Methods:

  • Literature review of recent publications.
  • Analysis of studies on miRNA regulation in cancer.
  • Synthesis of information on miRNA-based anticancer drug development.

Main Results:

  • miRNAs play a significant role in regulating protein-coding gene expression.
  • miRNAs are involved in both normal and pathological cellular processes.
  • miRNAs are crucial in understanding and overcoming chemoresistance.

Conclusions:

  • miRNAs are key regulators in cancer development and progression.
  • Understanding miRNA-mediated chemoresistance is vital for effective cancer therapy.
  • miRNAs represent promising targets for the development of next-generation anticancer drugs.