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US perspective on gluten-related diseases
Maureen M Leonard1, Brintha Vasagar2
1Center for Celiac Research, Massachusetts General Hospital for Children, Boston, MA, USA.
Clinical and Experimental Gastroenterology
|February 5, 2014
Summary
Gluten-related disorders, including celiac disease and non-celiac gluten sensitivity, are rising globally. This review examines their epidemiology, diagnosis, and potential risk factors, highlighting the need for further research.
Area of Science:
- Immunology
- Gastroenterology
- Epidemiology
Background:
- Increasing incidence of allergic and autoimmune diseases globally.
- Significant rise in celiac disease and non-celiac gluten sensitivity in the US.
- Wheat proteins, including gluten, are recognized as allergens.
Purpose of the Study:
- Review current knowledge on gluten-related disorder epidemiology worldwide.
- Focus on diagnostic trends and potential risk factors.
- Address the unexplained increase in gluten-related disorders.
Main Methods:
- Literature review of epidemiological studies.
- Analysis of diagnostic trends in gluten-related disorders.
- Evaluation of potential environmental and genetic risk factors.
Main Results:
- Documented rise in celiac disease incidence in the US.
- Increased diagnosis of non-celiac gluten sensitivity.
- Gluten identified as a common wheat allergen.
Conclusions:
- Gluten-free diet is an effective treatment.
- Further research is needed on the development and rising incidence of gluten-related disorders.
- Understanding epidemiology and risk factors is crucial for public health.
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