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Updated: May 3, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
[A young boy with pulmonary tuberculosis].
Marijn J Schuurman1, Bettina Loza, Janneke de Vries
1Viecuri Medisch Centrum, Venlo.
Tuberculosis is rare in young children in the Netherlands, but atypical pneumonia warrants testing. Early diagnosis and treatment of pediatric tuberculosis lead to full recovery.
Area of Science:
- Pediatrics
- Infectious Diseases
- Radiology
Background:
- Pediatric tuberculosis is uncommon in the Netherlands, posing risks of miliary tuberculosis or tuberculous meningitis in young children.
- Tuberculosis (TB) is a significant global health concern, particularly in developing countries.
Observation:
- A 12-month-old boy presented with persistent cough and fever, initially treated for community-acquired pneumonia without improvement.
- Chest X-ray revealed middle lobe infiltration, and empirical pneumonia treatment failed, prompting further investigation.
Findings:
- Positive tuberculin skin test results indicated tuberculosis infection.
- The child fully recovered after initiating tuberculostatic treatment.
- Subsequent confirmation of open tuberculosis in a family member in Turkey, where the child had recently visited, identified the source of infection.
Implications:
- Atypical pneumonia in children necessitates tuberculosis testing, even with a seemingly negative exposure history.
- Prompt diagnosis and treatment are crucial for favorable outcomes in pediatric tuberculosis.
- Physicians should maintain a high index of suspicion for tuberculosis in children presenting with persistent respiratory symptoms, regardless of geographical location or perceived exposure risk.
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