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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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Induced murine models of systemic lupus erythematosus
Yuan Xu1, Leilani Zeumer, Westley H Reeves
1Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, USA.
Methods in Molecular Biology (Clifton, N.J.)
|February 6, 2014
Abstract:
Induced mouse models of systemic lupus erythematosus (SLE) have been developed to complement the spontaneous models. This chapter describes the methods used in the pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of which have been extensively used. We will also outline the specific mechanisms of systemic autoimmunity that can be best characterized using each of these models.
