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Updated: May 3, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Aspewentins A-C, norditerpenes from a cryptic pathway in an algicolous strain of Aspergillus wentii
Feng-Ping Miao1, Xiao-Rui Liang, Xiang-Hong Liu
1Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , Yantai 264003, People's Republic of China.
Abstract:
Through addition of suberoylanilide hydroxamic acid, two new aromatic norditerpenes, aspewentins A (1) and B (2), along with an oxygenated derivative, aspewentin C (3), were obtained from the culture of an Aspergillus wentii strain (na-3) isolated from the tissue of the brown alga Sargassum fusiforme. The structures and absolute configurations were unambiguously elucidated by spectroscopic analyses and quantum chemical calculations. Aspewentins A-C were produced before sporulation and exhibited potent bioactivities against some marine-derived organisms.
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