Gusperimus: immunological mechanism and clinical applications

Miklos Perenyei1, David R W Jayne1, Oliver Floßmann2

  • 1Medical Sciences Division, University of Oxford, Oxford, Lupus and Vasculitis Clinic, Addenbrookes Hospital, Cambridge and Department of Nephrology, Royal Berkshire Hospital, Reading, UK.

Gusperimus is an immunosuppressive drug with a unique mode of action. We review its effects on different arms of the immune system and the current evidence for clinical applications, particularly in the treatment of transplant rejection and ANCA-associated vasculitis.