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Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

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Curcumin nanoemulsion for transdermal application: formulation and evaluation.

Heni Rachmawati¹, Dewa Ken Budiputra, Rachmat Mauludin

¹Department of Pharmacy, Bandung Institute of Technology , Bandung , Indonesia.

Drug Development and Industrial Pharmacy

|February 8, 2014

Summary

This summary is machine-generated.

This study developed a stable curcumin nanoemulsion for improved transdermal delivery. The nanoemulsion enhanced curcumin stability and significantly increased its skin permeation.

Keywords:

Curcumin Higuchi release profile self assembly nanoemulsion shed snake skin transdermal

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Curcumin, a natural compound, has limited bioavailability and stability for therapeutic applications.
Transdermal drug delivery offers a non-invasive route for systemic drug administration.

Purpose of the Study:

To develop and characterize a curcumin nanoemulsion for enhanced transdermal delivery.
To evaluate the stability and in vitro permeation of curcumin from the nanoemulsion system.

Main Methods:

Nanoemulsion preparation via self-nanoemulsification using glyceryl monooleate, Cremophor RH40, and polyethylene glycol 400.
Characterization of nanoemulsion properties including particle size, PDI, zeta potential, and physical stability.
In vitro permeation studies using a modified vertical diffusion cell and Python reticulatus snake skin.

Main Results:

A stable nanoemulsion with a curcumin loading capacity of 350 mg/10 g oil phase was successfully prepared.
Optimized nanoemulsion exhibited a mean droplet diameter of 85.0 ± 1.5 nm, PDI of 0.18 ± 0.0, and zeta potential of -5.9 ± 0.3 mV.
Nanoemulsification improved curcumin stability and significantly enhanced its permeation flux, altering release kinetics to a Higuchi profile.

Conclusions:

The developed curcumin nanoemulsion system is effective for transdermal delivery.
Nanoemulsification enhances curcumin's stability and skin permeability, offering a promising approach for therapeutic applications.