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Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis
Fakir Shahidullah Tareq1, Min Ah Lee, Hyi-Seung Lee
1Department of Marine Biotechnology, University of Science and Technology , Republic of Korea.
Abstract:
Gageotetrins A-C (1-3), a unique class of linear lipopeptides, consisting of di- and tetrapeptides and a new fatty acid were isolated from a Marine Bacillus subtilis. The structures of 1-3 were assigned by spectroscopic data and their absolute stereochemistries were ascertained by chemical derivatization. Compounds 1-3 displayed good antimicrobial activities with MIC values of 0.01-0.06 μM. However, these compounds failed to register any cytotoxicity (GI50 > 30 μg/ml) against human cancer cell lines.
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