Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

1.6K
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
1.6K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

1.7K
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
1.7K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

1.5K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.5K
Analgesia and Pain Management01:25

Analgesia and Pain Management

3.3K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
3.3K
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

2.0K
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
2.0K
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

7.2K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Holographic lasing with dielectric metasurfaces.

Science advances·2026
Same author

Legal Framework and Practical Challenges of Secondary Use of Medical Data in Japan.

Studies in health technology and informatics·2026
Same author

Effect of Positive End-expiratory Pressure on Sevoflurane Washout Times from Anesthesia Workstations.

The journal of medical investigation : JMI·2026
Same author

Effect of glucose load on metabolism in patients with type 2 diabetes during elective surgery using remifentanil-induced anesthesia:a randomized controlled trial.

The journal of medical investigation : JMI·2026
Same author

The Role of Green Infrastructure in Enhancing Flood Resilience: A Spatial Perspective.

Environmental management·2026
Same author

Spatio-spectrally Tailored Multimode Metasurface Lasers in the Visible Range.

Nano letters·2026

Related Experiment Video

Updated: May 3, 2026

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

15.2K

Opioid-induced cardioprotection.

Katsuya Tanaka, Judy R Kersten, Matthias L Riess1

  • 1Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226. mriess@mcw.edu.

Current Pharmaceutical Design
|February 8, 2014
PubMed
Summary
This summary is machine-generated.

Opioid receptor activation shows promise in protecting the heart from ischemia/reperfusion injury. This review explores endogenous and exogenous opioids for potential cardioprotective drug development.

More Related Videos

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
07:40

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

1.9K
In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

2.6K

Related Experiment Videos

Last Updated: May 3, 2026

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

15.2K
Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
07:40

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

1.9K
In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

2.6K

Area of Science:

  • Cardiology
  • Pharmacology
  • Molecular Biology

Background:

  • Ischemic heart disease and myocardial infarction are major causes of death.
  • G-protein coupled receptor activation, including opioid receptors, demonstrates cardioprotective effects.
  • The specific roles of different opioid receptor subtypes (κ, δ, µ) in cardioprotection are complex and require further elucidation.

Purpose of the Study:

  • To review the cardioprotective effects of endogenous and exogenous opioids against myocardial ischemia/reperfusion injury.
  • To discuss the mechanisms of opioid-mediated cardioprotection, including receptor interactions and cross-talk.
  • To explore implications for human cardioprotection and future drug development.

Main Methods:

  • Review of scientific literature on opioid peptides and exogenous opioids (morphine, fentanyl, etc.).
  • Analysis of studies investigating opioid receptor activation and its effects on myocardial ischemia/reperfusion.
  • Examination of receptor heterodimerization, cross-talk, and interactions with other cardioprotective strategies.

Main Results:

  • κ- and/or δ-opioid receptor activation is directly involved in myocardial protection.
  • The role of µ-opioid receptors in cardioprotection is less clear.
  • Differential receptor affinities and receptor cross-talk complicate the understanding of opioid-mediated cardioprotection.

Conclusions:

  • Opioids offer potential for cardioprotection against ischemia/reperfusion injury.
  • Further research into receptor interactions is crucial for optimizing opioid-based therapies.
  • Targeted drug development could improve myocardial salvage in patients with ischemic heart disease.