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[Investigation of S100A1 expression in normal ovarian tissues]
Akusherstvo I Ginekologiia
|February 8, 2014
Summary
S100A1 protein is expressed in several normal ovarian tissues, including nerves and granulosa cells. This finding reduces S100A1
Area of Science:
- Biochemistry
- Oncology
- Gynecologic Pathology
Context:
- S100 protein family comprises calcium-binding proteins.
- Increased S100A1 expression is observed in various tumors.
- Previous studies on S100A1 in ovarian tissues relied on limited tissue microarrays.
Purpose:
- To evaluate S100A1 expression in morphologically normal ovarian tissues using immunohistochemistry.
- To determine the utility of S100A1 as a biomarker for ovarian malignancy.
Summary:
- S100A1 expression was assessed in 40 normal ovarian tissue samples.
- Immunopositivity for S100A1 was detected in ovarian nerves, rete ovarii, granulosa cells (follicular cysts, corpus luteum, mature follicles), and corpus luteal cysts.
- Inclusion epithelial cysts were negative for S100A1.
Impact:
- S100A1 expression in normal ovarian tissues lowers its specificity as a malignancy biomarker.
- Immunohistochemical staining for S100A1 may aid in differentiating follicular from inclusion cysts.
