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SIRT1 in neurodevelopment and brain senescence

A Zara Herskovits1, Leonard Guarente2

  • 1Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Department of Biology and Glenn Laboratories for the Science of Aging, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 68-280, Cambridge, MA 02139, USA.

Neuron
|February 11, 2014
PubMed
Summary

Sirtuins, like SIRT1, are NAD+-dependent enzymes crucial for neuronal health, aging, and memory. Activating SIRT1 shows promise for treating neurodegenerative diseases.

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