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Alpha-synuclein lipid-dependent membrane binding and translocation through the α-hemolysin channel

Philip A Gurnev1, Thai Leong Yap2, Candace M Pfefferkorn2

  • 1Physics Department, University of Massachusetts, Amherst, Massachusetts; Section on Molecular Transport, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Biophysical Journal
|February 11, 2014
PubMed
Summary

Alpha-synuclein (α-syn) interactions with membranes are key to Parkinson disease. Using alpha-hemolysin channels, researchers probed α-syn binding and translocation, revealing lipid composition and electric field influence.

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