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Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice.

John A Kennard1, Fiona E Harrison1

  • 1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, United States.

Behavioural Brain Research
|February 11, 2014
PubMed
Summary

Vitamin C (ascorbate) improved spatial memory in aging mice, but not in Alzheimer

Keywords:
APP/PSEN1AgingAlzheimer's diseaseDopamineModified Y-mazeSpatial memoryVitamin C

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • Alzheimer's disease (AD) is characterized by cognitive decline, including spatial memory impairment.
  • Vitamin C (ascorbate, ASC) is an essential antioxidant with potential neuroprotective roles.
  • Understanding Vitamin C's impact on brain function, particularly in AD models, is crucial.

Purpose of the Study:

  • To investigate the effects of acute intravenous Vitamin C administration on spatial memory in an Alzheimer's disease mouse model (APP/PSEN1).
  • To examine Vitamin C uptake in various tissues and its correlation with behavioral outcomes.
  • To determine if Vitamin C treatment influences monoamine levels in the brain.

Main Methods:

  • APP/PSEN1 and wild-type mice of different ages (3, 9, 20 months) received intravenous Vitamin C or saline.
  • Spatial memory was assessed using the Modified Y-maze task 45 minutes post-injection.
  • Tissue Vitamin C levels were measured, and brain monoamine levels (dopamine, DOPAC) were analyzed.

Main Results:

  • Spatial memory declined with age in both mouse groups.
  • Vitamin C treatment significantly improved spatial memory performance in 9-month-old APP/PSEN1 and wild-type mice.
  • Acute Vitamin C administration did not alter dopamine or DOPAC levels in the nucleus accumbens.

Conclusions:

  • The Modified Y-maze is sensitive to age-related memory deficits but not specifically to amyloid pathology in this model.
  • Acute Vitamin C administration can enhance short-term spatial memory in aging mice.
  • The memory-enhancing effects of Vitamin C in this context are not mediated by changes in AD neuropathology or monoamine signaling.