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Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging
Danbi Jung1, Sukhendu Maiti, Jae Hong Lee
1Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
Abstract:
Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.

