Related Experiment Video
Updated: May 3, 2026

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
Published on: November 1, 2019
Portion size effects on weight gain in a free living setting
Simone A French1, Nathan R Mitchell, Julian Wolfson
1Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Objective:
Examine the effect of weekday exposure over 6 months to different lunch sizes on energy intake and body weight in a free-living sample of working adults.
Methods:
Adults (n = 233) were randomly assigned to one of three lunch size groups (400 kcal, 800 kcal, and 1,600 kcal) or to a no-free lunch control group for 6 months. Weight and energy intake were measured at baseline, and months 1, 3, and 6.
Results:
Lunch energy was significantly higher in the 800 and 1,600 kcal groups compared with the 400 kcal group (P < 0.0001). Total energy was significantly higher for the 1,600 kcal group compared with the 400 and 800 kcal groups (P = 0.02). Body weight change at 6 months did not significantly differ at the 5% level by experimental group (1,600 kcal group: +1.1 kg (SD = 0.44); 800 kcal group: -0.1 kg (SD = 0.42); 400 kcal group: -0.1 kg (SD = 0.43); control group: 1.1 (SD = 0.42); P = 0.07). Weight gain over time was significant in the 1,600 kcal box lunch group (P < 0.05).
Conclusions:
Weekday exposure for 6 months to a 1,600 kcal lunch caused significant increases in total energy intake and weight gain.
Related Concept Videos
Regulation of Food Intake
Drug Dosing: Obese Patients
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Binge Eating Disorders
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Nature and Nurture

