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Updated: May 3, 2026

Applications of the Single-probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions
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Nano-LC/MALDI-MS using a column-integrated spotting probe for analysis of complex biomolecule samples

Yusaku Hioki1, Ritsuko Tanimura, Shinichi Iwamoto

  • 1Koichi Tanaka Laboratory of Advanced Science and Technology, Shimadzu Corporation, 1, Nishinokyo-Kuwabara-cho, Nakagyo-ku, Kyoto 604-8511, Japan.

Analytical Chemistry
|February 12, 2014
PubMed
Summary

A novel direct-spotting system integrates nanoflow liquid chromatography with matrix-assisted laser desorption/ionization mass spectrometry, enhancing protein analysis by preventing eluate diffusion and improving sensitivity for complex biological samples.

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