APRIL mediates peritoneal B-1 cell homeostasis
Vishal J Sindhava1, Jean L Scholz1, William Stohl2
1Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, United States.
Immunology Letters
|February 12, 2014
Summary
A proliferation-inducing ligand (APRIL) is crucial for maintaining peritoneal B-1 cells, unlike B lymphocyte stimulator (BLyS). APRIL likely binds to heparan sulfate proteoglycans (HSPG) on these cells, with peritoneal macrophages being a key source.
Area of Science:
- Immunology
- Cell Biology
Background:
- B lymphocyte stimulator (BLyS) and A proliferation-inducing ligand (APRIL) are cytokines in the TNF superfamily.
- These cytokines are known to be important for B-2 cell development and survival.
- The role of these cytokines in B-1 cell biology is less understood.
Purpose of the Study:
- To investigate the roles of APRIL and BLyS in the maintenance of peritoneal B-1 cells.
- To determine the receptor and source of APRIL in the peritoneal cavity.
Main Methods:
- Utilized knockout mouse models to study B-1 cell populations.
- Analyzed the expression of APRIL and its potential receptors.
Main Results:
- A proliferation-inducing ligand (APRIL), but not B lymphocyte stimulator (BLyS), was found to be essential for peritoneal B-1 cell maintenance.
- Evidence suggests APRIL interacts with heparan sulfate proteoglycans (HSPG) on B-1 cells, not the TACI receptor.
- Peritoneal macrophages were identified as a significant source of APRIL within the peritoneal environment.
Conclusions:
- APRIL plays a critical role in sustaining peritoneal B-1 cell populations.
- The mechanism of APRIL action on B-1 cells involves HSPG binding.
- Peritoneal macrophages are a likely local source of APRIL, contributing to B-1 cell homeostasis.
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