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Published on: January 28, 2020
Long-term outcomes of dialysis patients after coronary revascularization: a population-based cohort study in Taiwan
Chu-lin Chou1, Tsung-cheng Hsieh1, Chih-hsien Wang2
1Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
Insights
For dialysis patients, coronary artery bypass grafting (CABG) and coronary stenting offer better survival rates than percutaneous transluminal coronary angioplasty (PTCA). Age influences optimal revascularization strategy for improved outcomes.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Interventional Cardiology
Background:
- Outcomes of coronary revascularization in dialysis patients remain unclear.
- This study investigates Taiwanese dialysis patients undergoing coronary artery bypass grafting (CABG), percutaneous transluminal coronary angioplasty (PTCA), or coronary stenting.
Purpose of the Study:
- To compare the survival and adverse event rates of dialysis patients after different coronary revascularization procedures.
- To identify age-specific optimal revascularization strategies for dialysis patients.
Main Methods:
- Utilized the National Health Research Institute database for a cohort of 1,287 dialysis patients.
- Analyzed outcomes for patients undergoing initial coronary revascularization between 1997 and 2008.
Main Results:
- Seven-year survival rates were significantly higher for CABG (69%) and stenting (68%) compared to PTCA (57%).
- Adjusted analyses showed reduced all-cause mortality for CABG (HR 0.695) and stenting (HR 0.721) versus PTCA.
- Older patients (≥65) benefited more from CABG, while younger patients (<65) showed better survival with stenting compared to PTCA. Stenting was associated with a higher risk of recurrent acute myocardial infarction (AMI).
Conclusions:
- CABG and coronary stenting are associated with improved survival in dialysis patients compared to PTCA.
- Age stratification reveals that CABG is superior for patients ≥65 years, while stenting is better for patients <65 years, compared to PTCA.
- Coronary stenting increases the risk of recurrent AMI, particularly in older dialysis patients.
Background And Aims:
The outcomes of Chinese patients undergoing dialysis after coronary revascularization are unknown. We examined the outcomes of Taiwanese dialysis patients after coronary artery bypass grafting (CABG), percutaneous transluminal coronary angioplasty (PTCA), or coronary stenting.
Methods:
Using data from the National Health Research Institute database, we determined the outcomes of 1,287 dialysis patients who underwent initial coronary revascularization between 1997 and 2008.
Results:
The 7-year overall survival rates were 69 ± 4%, 68 ± 3%, and 57 ± 2% for the CABG, stent, and PTCA patients (p = 0.001), respectively. After demographic and comorbidity adjustment, hazard ratios (HRs) for all-cause death in the CABG (vs. PTCA) and stent (vs. PTCA) patients were 0.695 (p = 0.015) and 0.721 (p = 0.009). Additionally, no significant difference in all-cause death was found between the CABG and stent patients. Moreover, the ≥65-year-old CABG group patients and the <65-year-old coronary stent group patients showed better survival than the PTCA group patients. Compared with the PTCA and CABG groups, the coronary stent group was significantly associated with a higher risk for recurrent acute myocardial infarction (AMI). Based on age stratification, the ≥65-year-old stent group had a higher risk for recurrent AMI than the PTCA group (HR, 1.562; p = 0.026).
Conclusions:
Chinese patients undergoing dialysis who underwent CABG or coronary stenting had better survival than those who underwent PTCA. Moreover, being ≥65 years old, CABG shows better survival compared with PTCA; being <65 years old, coronary stenting show better survival compared with PTCA.
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