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Updated: May 3, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
Metallic implant drug/device combinations for controlled drug release in orthopaedic applications
Jessica A Lyndon1, Ben J Boyd2, Nick Birbilis1
1Department of Materials Engineering, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Abstract:
The study of metallic drug/device combinations for controlled drug release in orthopaedic applications has gained significant momentum in the past decade, particularly for the prevention and reduction of implant associated infection. Such combinations are commonly based upon a permanent metallic implant (such as stainless steel or titanium) and are then coated with a drug-eluting polymer or ceramic system. Drug elution is also possible from the implant itself by utilising metallic foams, porous architectures and bioresorbable metals. This review will explore the current research into metallic implant drug/device combinations via a critical review of the relevant literature.
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