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Updated: May 3, 2026
09:16
Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy
Published on: September 11, 2015
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Epidermal growth factor, from gene organization to bedside.
Fenghua Zeng1, Raymond C Harris2
1Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States.
Seminars in Cell & Developmental Biology
|February 12, 2014
Summary
Epidermal growth factor (EGF) and its receptor pathway are crucial for cell growth and development. This review highlights EGF's roles in human diseases, from discovery to current research.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Epidermal Growth Factor (EGF) discovered in 1962 by Dr. Stanley Cohen.
- EGF is a key peptide growth factor activating EGF receptors.
- The EGF/EGF receptor pathway regulates cell proliferation, differentiation, and migration, particularly in epithelial cells.
Purpose of the Study:
- To review the gene organization and tissue distribution of EGF.
- To emphasize the biological and pathological roles of EGF in human diseases.
Main Methods:
- Literature review of studies on EGF and its signaling pathway.
- Analysis of EGF's involvement in cellular processes and disease.
Main Results:
- EGF signaling is fundamental to normal development.
- Dysregulation of EGF pathway is implicated in various human diseases.
Conclusions:
- EGF and its receptor pathway are vital in cellular functions.
- Understanding EGF's roles is critical for disease research and therapeutic strategies.
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