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Acute cerebral and peripheral circulation disorders.

K Klein1, M Klein

  • 13rd Medical Department of PH Baumgarten, Wien, Austria.

Zeitschrift Fur Alternsforschung
|January 1, 1988
PubMed
Summary
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Dextrans (40 and 60/70) rapidly counteract microcirculation failure in conditions like stroke and shock. These solutions improve flow, metabolism, and offer volume replacement, enhancing patient recovery, especially in geriatrics.

Area of Science:

  • Medical Sciences
  • Pharmacology

Background:

  • Acute ischemic conditions and shock syndromes present significant therapeutic challenges.
  • Microcirculation insufficiency is a key pathophysiological factor in these critical states.

Purpose of the Study:

  • To evaluate the efficacy of Dextrans in managing acute cerebral ischemia, peripheral arterial disease, and shock syndromes.
  • To assess the benefits of Dextran administration on microcirculation and overall patient outcomes.

Main Methods:

  • Administration of Dextrans (40 and 60/70) to address microcirculation insufficiency.
  • Concurrent management of blood pressure, cardiac, metabolic, and electrolyte disorders.
  • Use of analgesics and antibiotics as needed.

Main Results:

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  • Dextrans increased reduced microflow and metabolism, exerting antithrombotic effects.
  • Dextran 60 (70) demonstrated superior volume replacement (up to 25-30% of lost volume) compared to blood and gelatine.
  • Significant improvements in pathophysiological and clinical dysfunctions, and rehabilitation were observed.

Conclusions:

  • Dextran therapy is effective in counteracting microcirculation failure in various critical conditions.
  • Dextran 60 (70) offers advantages in efficacy, safety, and cost-effectiveness for volume replacement.
  • Dextran-based therapeutic strategies show high success rates, particularly in geriatric patients.