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Related Concept Videos

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Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Related Experiment Video

Updated: May 3, 2026

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
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Mesenchymal stem cell trials for pulmonary diseases.

Mariana A Antunes1, John G Laffey, Paolo Pelosi

  • 1Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Journal of Cellular Biochemistry
|February 12, 2014
PubMed
Summary

Mesenchymal stem/stromal cells (MSCs) show promise for treating lung diseases like emphysema and fibrosis. This review examines current clinical trials and future directions for MSC therapy in respiratory conditions.

Keywords:
ACUTE RESPIRATORY DISTRESS SYNDROMEEMPHYSEMAFIBROSISMESENCHYMAL STEM CELLS

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Area of Science:

  • Regenerative Medicine
  • Pulmonary Medicine
  • Stem Cell Biology

Background:

  • Adult tissues possess self-repair capabilities via resident stem cells.
  • Lung resident stem cells are a potential therapy but their biology is not fully understood.
  • Mesenchymal stem/stromal cells (MSCs) are being investigated as an alternative cell therapy for lung diseases.

Purpose of the Study:

  • To review ongoing clinical trials of MSCs for lung diseases.
  • To critically evaluate the evidence supporting MSC use in pulmonary conditions.
  • To discuss the future translational pathway for MSC-based lung disease therapies.

Main Methods:

  • Review of preclinical studies on MSCs for various lung disorders.
  • Analysis of data from ongoing clinical trials involving MSCs.
  • Discussion of the current understanding of MSC biology and therapeutic mechanisms.

Main Results:

  • Preclinical studies show promising MSC efficacy in emphysema, bronchopulmonary dysplasia, fibrosis, and acute respiratory distress syndrome.
  • Ongoing clinical trials are exploring MSCs for diverse lung pathologies.
  • Significant interest exists in the therapeutic potential of bone marrow-derived MSCs.

Conclusions:

  • MSCs represent a promising cell therapy for various lung diseases.
  • Further research and clinical evaluation are needed to optimize MSC therapy for respiratory conditions.
  • Understanding MSC biology is crucial for advancing their clinical application in lung disease treatment.