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Related Experiment Videos

Optic nerve head drusen associated with abnormally small optic discs.

J B Jonas1, G C Gusek, I Guggenmoos-Holzmann

  • 1Department of Ophthalmology, University Erlangen-Nürnberg, BRD.

International Ophthalmology
|December 1, 1987
PubMed
Summary

Optic nerve head drusen are associated with significantly smaller optic disc areas. This finding suggests mechanical compression from a small optic nerve scleral canal may contribute to drusen formation.

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Area of Science:

  • Ophthalmology
  • Neuro-ophthalmology

Background:

  • Optic nerve head drusen are abnormal deposits within the optic nerve.
  • Their etiology remains incompletely understood, with theories suggesting mechanical or vascular factors.

Purpose of the Study:

  • To evaluate the absolute optic disc size in eyes with optic nerve head drusen.
  • To investigate the relationship between optic disc size and drusen formation.

Main Methods:

  • Littmann's method was used to correct magnification in central fundus photographs.
  • Absolute optic disc area was measured in 26 eyes with visible optic nerve head drusen.
  • Reproducibility of measurements was assessed (intraobserver and interobserver).

Main Results:

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  • Eyes with optic nerve head drusen had significantly smaller optic nerve head areas (1.79 ± 0.50 mm²) compared to normal standards (2.89 ± 0.76 mm²).
  • Drusen were predominantly located at the superior and inferior optic disc borders.
  • Measurement reproducibility was high (intraobserver CV 0.06, interobserver CV 0.11).

    • Conclusions:

    • Abnormally small optic discs, potentially due to a small optic nerve scleral canal, may cause mechanical compression of axonal flow.
    • This compression is hypothesized to contribute to the formation of optic nerve head drusen.
    • Pseudoneuritis associated with small optic discs may precede acquired optic nerve head drusen.