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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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Related Experiment Video

Updated: May 3, 2026

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
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Multiple osteolytic lesions.

Divya Vinayachandran1, Sathasivasubramanian Sankarapandian2

  • 1Department of Oral Medicine and Radiology, Sri Ramaswamy Memorial Kattankulathur Dental College and Hospitals, Chennai, Tamil Nadu, India.

Journal of Clinical Imaging Science
|February 12, 2014
PubMed
Summary

Oral symptoms can indicate serious systemic diseases. This case highlights how jaw enlargement and limb lesions led to diagnosing multiple myeloma, a life-threatening condition.

Keywords:
Multiple myelomamaxillofacial lesionsosteolytic lesions

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Area of Science:

  • Oral Medicine
  • Oncology
  • Pathology

Background:

  • Systemic diseases can manifest with oral symptoms, sometimes indicating severe underlying conditions.
  • Early recognition of oral signs is crucial for timely diagnosis and treatment of life-threatening diseases.

Purpose of the Study:

  • To present a case where oral manifestations led to the diagnosis of multiple myeloma.
  • To emphasize the importance of investigating oral symptoms for systemic disease detection.

Main Methods:

  • Case report detailing clinical presentation and diagnostic process.
  • Review of patient's oral and systemic findings.

Main Results:

  • Patient presented with significant mandibular enlargement and lower limb lesions.
  • Further investigations confirmed the diagnosis of multiple myeloma.

Conclusions:

  • Mandibular enlargement and lower limb lesions can be initial indicators of multiple myeloma.
  • Thorough investigation of oral manifestations is vital for diagnosing grave systemic illnesses.