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Updated: May 3, 2026

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Simultaneous fMRI and Electrophysiology in the Rodent Brain

Published on: August 19, 2010

Simultaneous Multi-Slice fMRI using spiral trajectories.

Benjamin Zahneisen¹, Benedikt A Poser², Thomas Ernst¹

¹University of Hawaii, Department of Medicine, John A. Burns School of Medicine, Honolulu, HI, USA.

|February 13, 2014

Summary

This summary is machine-generated.

Simultaneous Multi-Slice (SMS) fMRI with a novel blipped-spiral sequence achieves ultra-fast whole-brain imaging at 168 ms. This high temporal resolution enables precise measurement of Blood-Oxygen-Level-Dependent (BOLD) lag times in the visual cortex.

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High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain

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Published on: May 10, 2012

Area of Science:

Magnetic Resonance Imaging (MRI)
Neuroimaging
Functional MRI (fMRI)

Background:

Parallel imaging accelerates MRI but offers limited temporal resolution gains in fMRI due to long echo times for BOLD contrast.
Simultaneous Multi-Slice (SMS) imaging significantly enhances fMRI temporal resolution by acquiring multiple slices concurrently.
Blipped-CAIPI EPI sequences improve slice separation in SMS fMRI by optimizing 3D k-space sampling.

Purpose of the Study:

To introduce and evaluate a blipped-spiral SMS sequence for ultra-fast fMRI.
To demonstrate the capability of this sequence for high-resolution, whole-brain coverage.
To assess its utility in measuring dynamic BOLD lag times and creating cortical maps.

Main Methods:

Development of a blipped-spiral SMS sequence combining spiral trajectories with blipped-CAIPI encoding.
Acquisition of fMRI data with nearly whole-brain coverage at 3mm isotropic resolution.
Utilizing visual/motor and retinotopic mapping paradigms to measure BOLD lag times.

Main Results:

The blipped-spiral SMS sequence achieved whole-brain coverage in 168 ms.
High temporal resolution enabled dynamic Blood-Oxygen-Level-Dependent (BOLD) lag time measurements.
Direct measurement of BOLD lag times in the visual cortex allowed for eccentricity mapping.

Conclusions:

The blipped-spiral SMS sequence offers a significant advancement for ultra-fast fMRI.
This technique provides unprecedented temporal resolution for dynamic BOLD signal analysis.
It facilitates precise mapping of functional parameters like BOLD lag time within the cortex.