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Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
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Secretin: historical perspective and current status.

William Y Chey1, Ta-Min Chang

  • 1From the Rochester Institute for Digestive Diseases and Sciences, Rochester, NY.

Pancreas
|February 13, 2014
PubMed
Summary
This summary is machine-generated.

Secretin, a key hormone, regulates pancreatic secretion and is vital for digestion. Its discovery, action, and clinical uses, including in diagnosing gastrinoma syndrome, are reviewed.

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Area of Science:

  • Gastroenterology and Endocrinology
  • Hormone research
  • Physiology

Background:

  • The review details the historical discovery, purification, and structural elucidation of secretin.
  • It covers the cloning of secretin and its receptor, and the development of sensitive assays.

Discussion:

  • Secretin is crucial for regulating exocrine pancreatic secretion, influenced by cholecystokinin and neurohormonal interactions.
  • Its release and action involve vagovagal reflexes and neurotransmitters, with insulin modulating its pancreatic effects.

Key Insights:

  • Secretin plays a dual role in the positive and negative regulation of pancreatic exocrine secretion.
  • Neurohormonal pathways, including vagovagal reflexes and insulin, are integral to secretin's function.
  • Clinical implications of altered secretin levels (hyper- and hyposecretinemia) are discussed.

Outlook:

  • Synthetic secretin is valuable for diagnostic procedures like secretin-enhanced MRI and gastrinoma syndrome diagnosis.
  • Therapeutic applications of secretin for chronic pancreatitis pain are under consideration.