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Updated: May 3, 2026
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Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
Published on: March 30, 2022
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Matrix metalloproteinases and their role in psoriasis
Alexandre Mezentsev1, Alexander Nikolaev1, Sergey Bruskin1
1Vavilov Institute of General Genetics RAS, Gubkina str., Bld. 3, 119991 Moscow, Russia.
Gene
|February 13, 2014
Summary
Matrix metalloproteinases (MMPs) contribute to psoriasis pathogenesis by altering skin structure, promoting inflammation, and affecting blood vessels. This review examines MMPs
Area of Science:
- Dermatology
- Pathology
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin disease.
- Matrix metalloproteinases (MMPs) are implicated in psoriasis pathogenesis.
- MMPs contribute to epidermal changes, angiogenesis, and immune cell infiltration.
Purpose of the Study:
- To review the role of MMPs in psoriasis pathogenesis.
- To assess the progress in understanding MMPs' involvement in psoriasis.
- To characterize novel pharmacological approaches targeting MMPs.
Main Methods:
- Literature review of studies on MMPs in psoriasis.
- Analysis of experimental data on MMP distribution and expression in healthy and lesional skin.
- Evaluation of clinical trial data for MMP inhibitors.
Main Results:
- MMPs modify epidermal structure and extracellular matrix composition in psoriasis.
- Differential expression of certain MMPs correlates with psoriasis severity.
- Current pharmacological approaches include oral MMP inhibitors like azasugars and phosphonamides.
Conclusions:
- MMPs play a significant role in psoriasis pathophysiology.
- Emerging MMP inhibitors are in clinical trials.
- Potential challenges exist in using MMP inhibitors, necessitating clear criteria for future drug development.
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