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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Related Experiment Video

Updated: May 3, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
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Convergent microRNA actions coordinate neocortical development.

Olga Barca-Mayo1, Davide De Pietri Tonelli

  • 1Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genoa, Italy.

Cellular and Molecular Life Sciences : CMLS
|February 13, 2014
PubMed
Summary

MicroRNAs (miRNAs) precisely regulate gene networks controlling neocortical development. This review focuses on how convergent miRNA actions coordinate neuronal generation, migration, and cortical layer formation in embryonic rodents.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Neocortical development involves intricate cellular processes like self-renewal, differentiation, and migration.
  • Precise molecular regulation of signaling pathways and extrinsic factors is crucial for corticogenesis.
  • While transcriptional regulation is key, microRNAs (miRNAs) are increasingly recognized as vital post-transcriptional regulators in central nervous system development.

Purpose of the Study:

  • To review in vivo validated microRNA-target interactions during embryonic rodent neocortical development.
  • To elucidate the role of miRNAs in the generation and migration of pyramidal-projection glutamatergic neurons.
  • To investigate how miRNAs contribute to the formation of cortical layers and explore the complexity of convergent miRNA actions.

Main Methods:

  • Literature review of validated in vivo microRNA-target interactions.
  • Focus on studies relevant to glutamatergic neuron development and cortical layer formation.
  • Analysis of convergent microRNA actions in neocortical development.

Main Results:

  • Identified key microRNA-target interactions critical for neocortical development.
  • Highlighted the role of miRNAs in pyramidal-projection glutamatergic neuron generation and migration.
  • Emphasized the significance of convergent miRNA actions in coordinating complex developmental processes.

Conclusions:

  • MicroRNAs are essential post-transcriptional regulators orchestrating neocortical development.
  • Convergent miRNA actions represent a complex regulatory layer crucial for precise control of neuronal development and cortical patterning.
  • Further research into convergent miRNA actions will unlock deeper understanding of neocortical development.