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In Vitro Model of Coronary Angiogenesis
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VEGF-B: a more balanced approach toward cardiac neovascularization?
Christian Kupatt1, Rabea Hinkel
1Medizinische Klinik I Klinikum Großhadern, Munich, Germany.
EMBO Molecular Medicine
|February 14, 2014
Abstract:
There is an urgent need for new pharmacologic approaches to combat the clinical consequences of ischemic cardiomyopathy. In this issue of EMBO Molecular Medicine, Kivelä et al show that transgenic expression of VEGF-B in the rat heart leads to expansion of the coronary arterial tree and an increase in functional coronary reserve, accompanied by a shift in myocardial metabolism from fatty acid to glucose utilization.
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