Early subclinical ventricular dysfunction in patients with insulin resistance
Giuseppina Novo1, Marinella Pugliesi, Claudia Visconti
1Chair of Cardiovascular Diseases, Center for the early Diagnosis of Preclinical and Multifocal Atherosclerosis and for Secondary Prevention of Cardiovascular Diseases, Division of Cardiology, University Hospital 'Paolo Giaccone', University of Palermo, Italy.
Journal of Cardiovascular Medicine (Hagerstown, Md.)
|February 14, 2014
Summary
Insulin resistance is linked to early heart dysfunction in individuals with cardiovascular risks. Higher HOMA-IR levels indicate subclinical ventricular dysfunction, suggesting a need for early screening and intervention to prevent heart failure.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Preventive Medicine
Background:
- Cardiovascular risk factors are prevalent.
- Early detection of heart failure is crucial.
- Insulin resistance may precede overt cardiovascular disease.
Purpose of the Study:
- To investigate the association between insulin resistance and subclinical echocardiographic signs of heart failure.
- To identify patients with cardiovascular risk factors who may benefit from early intervention.
Main Methods:
- 34 patients with cardiovascular risk factors were studied.
- Insulin resistance was assessed using Homeostasis Model Assessment of Insulin Resistance (HOMA-IR).
- Echocardiography was used to evaluate ventricular function and detect diastolic dysfunction.
Main Results:
- Patients with higher HOMA-IR levels showed statistically significant signs of subclinical ventricular dysfunction.
- Independent predictors of diastolic dysfunction included HOMA-IR, hypertension, waist circumference, HDL, and fasting glucose.
- HOMA-IR was the sole predictor influencing the Tei index.
Conclusions:
- Insulin resistance is commonly associated with subclinical left-ventricular dysfunction.
- Individuals with cardiovascular risk factors and elevated HOMA-IR warrant screening for early heart failure detection.
- Lifestyle changes and pharmacological interventions may prevent heart failure in this population.
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