Related Experiment Video
Updated: May 3, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Interventions for pediatric renovascular hypertension
Kevin E Meyers1, Anne Marie Cahill, Christine Sethna
1Department of Pediatrics, The Children's Hospital of Philadelphia and University of Pennsylvania, 1st Floor, Main Building, Cnr 34th Street and Civic Center Boulevard, Philadelphia, PA, 19026, USA, meyersk@email.chop.edu.
Insights
Renovascular disease causes hypertension in children. Treatments combining medical, angiographic, and surgical methods show success, though many children may still require medication.
Area of Science:
- Pediatric Nephrology
- Cardiovascular Medicine
- Interventional Radiology
Background:
- Renovascular disease is a significant cause of hypertension in 10-15% of prepubertal children.
- Advances in medical, angiographic, and surgical interventions are crucial for managing this condition.
Purpose of the Study:
- To review current and advancing interventions for renovascular disease and associated hypertension in children.
- To highlight the efficacy of combination therapy in pediatric patients.
Main Methods:
- Review of medical, angiographic, and surgical treatment modalities for renovascular hypertension in children.
- Analysis of outcomes for monotherapy and combination therapy approaches.
Main Results:
- Interventions including medical therapy, percutaneous angioplasty, and surgery are effective in treating renovascular disease.
- While often successful, up to two-thirds of children may require continued antihypertensive medication post-intervention.
Conclusions:
- Combination therapy for renovascular disease in children offers promising outcomes.
- Future improvements are expected with advancements in antihypertensive medications, angioplasty techniques, and vascular surgery expertise.
Abstract:
Renovascular disease is a cause of hypertension in 10 % to 15 % of prepubertal children. Interventions to address hypertension and causes of renovascular disease continue to advance. Successful interventions to treat renovascular disease include medical, angiographic, and surgical means, used alone or, more often, as combination therapy. Medical therapy is used to control the blood pressure prior to further intervention or in specific instances as long-term single therapy. Judicious use of percutaneous angioplasty and surgical intervention is usually successful in children with renal artery stenosis, although up to two-thirds of children will remain on antihypertensive medication after the procedure. Outcomes of combination therapy will continue to improve with advances in the use of antihypertensive medication in children, improvements in percutaneous angiography techniques, and progress in vascular surgical expertise.
More Related Videos
Related Concept Videos
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antihypertensive Drugs: Direct Renin Inhibitors
Hypertension V: Nursing Management
Acute Kidney Injury VI: Nursing Management
Hypertension IV: Drug Therapy and Lifestyle Modifications
Heart Failure V: Medical Management

