Wound infections with multi-drug resistant bacteria

Area of Science:

• Clinical Microbiology
• Infectious Diseases
• Antimicrobial Resistance

Background:

• Wound infections pose a significant public health challenge.
• Antibiotic misuse contributes to the rise of bacterial resistance and dissemination.

Purpose of the Study:

• To investigate the prevalence and antibiotic resistance patterns of multi-drug resistant (MDR) bacteria isolated from wound infections.
• To identify specific resistance profiles of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamases (ESBL) producing Gram-negative bacteria.

Main Methods:

• Analysis of 470 wound infection samples.
• Selective culturing using Metistaph-2 and ESBLs-Agar media for MRSA and ESBL bacteria, respectively.
• Antimicrobial sensitivity testing via the diffusion method.

Main Results:

• 27.6% of bacterial strains exhibited multi-drug resistance.
• Staphylococcus aureus was the predominant MDR isolate.
• MRSA and ESBL bacteria showed high resistance to aminoglycosides, quinolones, and third-generation cephalosporins, but lower resistance to fourth-generation cephalosporins.
• No vancomycin-resistant or vancomycin-intermediate Staphylococcus aureus strains were detected.

Conclusions:

• Knowledge of specific antibiotic resistance profiles is essential for implementing effective antibiotic cycling strategies.
• This approach can help mitigate the emergence and spread of increased bacterial resistance.