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Updated: Jan 22, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
A Novel Method of Obtaining Platelet Rich Fibrin from Rats and Quantifying Platelet Count
A F Grecu1, D C Grecu2, O Nica1
1PhD Researcher, University of Medicine and Pharmacy of Craiova, Romania.
Background And Objectives:
Rat experimentation is the first line of research by which a medical hypothesis is usually tested. Platelet Rich Fibrin (PRF) is a relatively new bio-material that has shown promise to enhance healing in the field of bone research and tissue engineering. In order to perform PRF based experiments on rats, a proper protocol of obtaining PRF from rats needs to be established.
Materials And Methods:
35 Wistar rats were used to obtain PRF by using cardiac puncture blood draw and quick subsequent centrifugation. The PRF samples wereanalyzed and compared to standard literature PRF composition.
Results:
PRF samples analysis showed persistent results pertaining to known PRF composition.
Conclusions:
Our experiment has shown that our protocol of obtaining PRF is capable of providing high quality PRF from rats.
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