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Intracranial volume inversely correlates with serum 25(OH)D level in healthy young women
Objectives:
Vitamin D is important in normal brain development. In animals low vitamin D level is associated with brain morphological alterations including enlargement of the brain. Whether a similar association exists in humans is unknown. Here we investigated the relationship between vitamin D and total intracranial volume as well as total volume of the cortical grey and cerebral white matter and that of the ventricles in young healthy women.
Methods:
To assess volumes we applied semi-automatic user-independent MR volumetry. For the vitamin D measurements automated electrochemiluminescence immunoassay was used.
Results:
We found a significant negative correlation between vitamin D and total intracranial volume as well as total cortical grey and cerebral white matter volumes.
Discussion:
This association may reflect a trait-like relationship between vitamin D and brain size possibly determined in early development.
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