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A model for cofactor use during HIV-1 reverse transcription and nuclear entry

Laura Hilditch1, Greg J Towers1

  • 1University College London, Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 90 Gower Street, London WC1E 6BT, United Kingdom.

Current Opinion in Virology
|February 15, 2014
PubMed
Summary

Human immunodeficiency virus type 1 (HIV-1) employs host proteins, such as capsid protein, cyclophilin A (CypA), and CPSF6, to facilitate early viral replication. This interaction helps HIV-1 evade immune responses and target specific chromatin for integration.

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