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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Updated: May 3, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Psoriasis: the visible killer.

Tiago Torres1, Nuno Bettencourt2

  • 1Department of Dermatology, Centro Hospitalar do Porto, Porto, Portugal; Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto, Porto, Portugal.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|February 15, 2014
PubMed
Summary
This summary is machine-generated.

Severe psoriasis patients face increased cardiovascular risks due to chronic inflammation. Early detection and multidisciplinary management of psoriasis and its comorbidities are crucial for preventing heart attacks and strokes.

Keywords:
Abordagem multidisciplinarAteroscleroseAtherosclerosisCardiovascular diseaseCardiovascular risk factorsDoença cardiovascularFatores de risco cardiovascularesInflamaçãoInflammationMultidisciplinary approachPsoriasisPsoríase

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Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis is a chronic inflammatory skin condition linked to significant comorbidities.
  • Severe psoriasis is associated with increased mortality from cardiovascular diseases like myocardial infarction and stroke.
  • Patients with psoriasis exhibit a higher prevalence of traditional cardiovascular risk factors.

Purpose of the Study:

  • To emphasize the link between psoriasis's chronic inflammation and cardiovascular disease (CVD) risk.
  • To highlight the necessity of managing psoriasis comorbidities and CVD.
  • To advocate for effective psoriasis treatment to reduce systemic inflammation.

Main Methods:

  • Review of existing literature on psoriasis, comorbidities, and cardiovascular outcomes.
  • Analysis of the role of chronic inflammation in psoriasis-related CVD.
  • Discussion of multidisciplinary care strategies for severe psoriasis patients.

Main Results:

  • Chronic inflammation in psoriasis may be an independent risk factor for CVD.
  • Psoriasis patients have elevated rates of diabetes, hypertension, dyslipidemia, and obesity.
  • Effective psoriasis treatment can mitigate systemic inflammation and potentially lower CVD risk.

Conclusions:

  • Early identification and treatment of psoriasis comorbidities and CVD are essential.
  • A multidisciplinary approach is vital for optimizing the care of severe psoriasis patients.
  • Managing systemic inflammation in psoriasis is key to preventing cardiovascular events.