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Related Experiment Video

Updated: May 3, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

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Published on: April 28, 2022

Basic Fibroblast Growth Factor in Scarless Wound Healing.

Sadanori Akita¹, Kozo Akino¹, Akiyoshi Hirano¹

¹Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University , Graduate School of Biomedical and Sciences, Nagasaki, Japan .

Advances in Wound Care

|February 15, 2014

Summary

Basic fibroblast growth factor (bFGF) promotes scarless wound healing by enhancing fibroblast proliferation and DNA synthesis. Early application of bFGF improves tissue texture and color, leading to better clinical outcomes.

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Area of Science:

Regenerative Medicine
Wound Healing Biology

Background:

Human amniotic fluid may be crucial for scarless wound healing.
Fibroblast proliferation is enhanced by amniotic fluid components.
Basic fibroblast growth factor (bFGF) is a key factor in wound healing.

Approach:

Investigated the role of bFGF in augmenting adult and fetal fibroblast mitogenic activities.
Utilized bFGF receptor blockers and anti-bFGF antibodies to assess bFGF's impact.
Examined the effect of bFGF on ERK and Akt phosphorylation in fibroblasts.

Key Points:

Adult wound healing often results in scar formation, affecting tissue texture and flexibility.
bFGF can normalize tissue texture and color, improving overall wound healing outcomes.
bFGF significantly increases fibroblast proliferation and DNA synthesis.

Conclusions:

bFGF activates ERK and Akt phosphorylation, driving fibroblast proliferation and DNA synthesis.
Early application of bFGF is recommended for optimal wound healing results.
bFGF holds significant potential for clinical applications in scarless wound healing.