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Facial memory deficits in myotonic dystrophy type 1
J L Kleberg1, C Lindberg, S Winblad
1Department of Psychology, University of Gothenburg, Gothenburg, Sweden; Department of Psychology, Uppsala University, Uppsala, Sweden.
Objectives:
To evaluate facial memory ability (FMA) in patients with myotonic dystrophy type 1 (DM1). We also explored the relationship between FMA and neuropsychological data, disease-related factors, and CTG repeat expansion size.
Materials And Methods:
Patients with DM1 (n = 33) and healthy subjects (n = 30) were tested with the faces task of the Rivermead Behavioural Memory Test - Extended version (RBMT-E) and an additional set of neuropsychological tests. Clinical data were collected, and CTG repeat size was quantified in blood lymphocytes.
Results:
Low results on the faces task were more common in patients with DM1 compared with healthy subjects (P < 0.05), with 36% of the patients showing a poor/impaired performance. DM1 patients with deficits in FMA performed significantly worse on tests measuring visual-construction ability and memory. Furthermore, these patients more often falsely recognised unknown faces as known. Deficits in FMA were not associated with any disease-related factor, including CTG repeat expansion size.
Conclusions:
These findings revealed deficits in FMA in the DM1 group, which was associated with reduced construction- and visual memory ability.
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