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Tumor evolution in response to chemotherapy: phenotype versus genotype

Nicholas E Navin1

  • 1Department of Genetics, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, TX 77030, USA.

Cell Reports
|February 18, 2014
PubMed
Summary

This study reveals that cellular phenotypes, not just genetics, drive therapy resistance in breast cancer. These findings challenge previous ideas about genetic bottlenecks during treatment.

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