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Updated: May 3, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

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[Dermatomyositis. Presentation of a mild to moderate case with early dysphagia]

M Sánchez Carbonell1, H Climent Antolí1, A L Leandro Fonseca1

  • 1Hospital Virgen de los Lirios, Alcoy, Alicante, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|February 18, 2014
PubMed

Insights

This case study highlights juvenile dermatomyositis treatment challenges. Initial therapies improved skin but not muscle weakness, necessitating further interventions.

Area of Science:

  • Pediatric Rheumatology
  • Dermatology
  • Immunology

Background:

  • Juvenile dermatomyositis (JDM) is a rare autoimmune disease affecting children.
  • It presents with characteristic skin rash and proximal muscle weakness.
  • Early diagnosis and treatment are crucial for optimal outcomes.

Observation:

  • A 12-year-old female presented with proximal muscle weakness and a skin rash.
  • Initial treatment with oral corticosteroids and methotrexate showed partial response.
  • Skin lesions improved, but muscle weakness persisted, and dysphagia developed.

Findings:

  • The patient required additional parenteral methylprednisolone pulses due to persistent muscle weakness and dysphagia.
  • Treatment decisions in JDM can be complex, requiring adjustments based on clinical response.
  • This case underscores the variability in JDM presentation and treatment efficacy.

Implications:

  • Highlights the need for individualized treatment strategies in pediatric rheumatology.
  • Emphasizes careful monitoring for treatment response and potential complications in JDM.
  • Informs clinical practice regarding the management of refractory juvenile dermatomyositis cases.

Keywords:
Dermatomiositis juvenilInitial treatmentJuvenile dermatomyositisMethylprednisoloneMetilprednisolonaTratamiento inicial

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