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A neglected epidemic: fungal infections in HIV/AIDS

Darius Armstrong-James1, Graeme Meintjes2, Gordon D Brown3

  • 1Imperial Fungal Diseases Group, Imperial College London, Department of Infectious Diseases and Immunity, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

Trends in Microbiology
|February 18, 2014
PubMed

Insights

Invasive fungal infections (IFIs) remain a leading cause of death in HIV patients, causing 50% of AIDS-related deaths. Improved management strategies are crucial to reduce mortality from these devastating infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • HIV/AIDS Research

Background:

  • Invasive fungal infections (IFIs) are a significant cause of mortality in individuals with Human Immunodeficiency Virus (HIV).
  • Despite advances in combined antiretroviral therapy (cART), IFIs contribute to approximately 1 million deaths annually, representing 50% of all AIDS-related deaths.
  • Historically, a lack of focus on IFIs in advanced HIV infection has resulted in critical management deficiencies.

Purpose of the Study:

  • To summarize the current understanding of AIDS-related mycoses.
  • To identify key action points for improving patient outcomes in IFIs.
  • To address the management flaws in advanced HIV infection.

Main Methods:

  • Review of current knowledge on AIDS-related mycoses.
  • Synthesis of findings from the EMBO AIDS-Related Mycoses Workshop (Cape Town, 2013).

Main Results:

  • IFIs are a major, yet often overlooked, cause of mortality in HIV patients.
  • Current management approaches for IFIs in advanced HIV are fundamentally flawed.
  • There is a critical need for targeted interventions and research in AIDS-related mycoses.

Conclusions:

  • Urgent focus on IFIs is required to reduce HIV-related mortality.
  • Implementing key action points from the workshop is essential for improving outcomes.
  • Addressing the management gaps in advanced HIV infection is paramount.
Keywords:
AIDSHIVfungal infectionimmunitymycoses

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