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Fine-tuned broad binding capability of human lipocalin-type prostaglandin D synthase for various small lipophilic

Satoshi Kume1, Young-Ho Lee2, Masatoshi Nakatsuji3

  • 1Laboratory of Biological Macromolecules, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan; Cellular Function Imaging Team, Division of Bio-function Dynamics Imaging, RIKEN Center for Life Science Technologies, 6-7-3, Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.

FEBS Letters
|February 18, 2014
PubMed

Keywords:
Binding thermodynamicDriving forceEnthalpy–entropy compensationHydrophobic effectIsothermal titration calorimetryLipocalin-type prostaglandin D synthaseProtein–ligand interaction

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