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Blinking in patients with clinically probable multiple system atrophy.

Matteo Bologna1, Luca Marsili, Nashaba Khan

  • 1Neuromed Institute IRCCS, Pozzilli (IS).

Movement Disorders : Official Journal of the Movement Disorder Society
|February 18, 2014
PubMed
Summary
This summary is machine-generated.

This study objectively assessed blinking in multiple system atrophy (MSA) patients. Findings reveal significant voluntary, spontaneous, and reflex blinking abnormalities in MSA-P and MSA-C phenotypes.

Keywords:
basal gangliablinkingbrainstemmovement controlmultiple system atrophy

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Area of Science:

  • Neurology
  • Ophthalmology
  • Movement Disorders

Background:

  • Facial motor abnormalities are noted in multiple system atrophy (MSA).
  • Objective assessment of blinking abnormalities in MSA is lacking.
  • This study addresses the gap in understanding MSA's impact on blinking.

Purpose of the Study:

  • To objectively evaluate blinking abnormalities in patients with multiple system atrophy (MSA).
  • To compare blinking kinematics between MSA phenotypes (MSA-P and MSA-C) and healthy controls (HCs).

Main Methods:

  • Enrolled 20 MSA-parkinsonian (MSA-P), 10 MSA-cerebellar (MSA-C) patients, and 20 HCs.
  • Utilized a 3D optoelectronic motion system to record blinking.
  • Analyzed blinking phases (voluntary, spontaneous, reflex) and blink reflex recovery.

Main Results:

  • MSA patients exhibited prolonged blink phase durations and reduced peak velocities.
  • Spontaneous blinking rate and kinematics were lower in MSA-P and MSA-C patients.
  • Blink reflex recovery was elevated in MSA patients compared to HCs.

Conclusions:

  • Objective blinking assessment reveals abnormalities in voluntary, spontaneous, and reflex blinking in MSA.
  • These findings suggest cortical-basal ganglia and brainstem dysfunction in MSA patients.
  • Dopaminergic medication did not influence observed blinking differences.